The origins of the company go back to 1879, when the druggist and businessman Carl Roth founded a material, colonial, dye and drug store in Karlsruhe .  In 1891, the Carl Roth drugstore received the title and privilege of purveyor to the court of the Grand Duchy of Baden . 
In 1928 the drugstore business was expanded to include a department for laboratory chemicals, and in 1945 a manufacturing and bottling department was added. In 1965, the chemicals department moved to a newly built facility on Schoemperlenstraße. In December 1969, Carl Roth sold the drugstore business, ending a 90-year tradition.
The Carl Roth wholesale business was continued in Schoemperlenstraße. In 1993, a high- bay warehouse for the range of laboratory supplies was built there, and in 1996 a shipping warehouse was set up. Even after the addition of an office building in 2001, the company's space requirements soon exceeded the existing premises. In 2003, the company acquired a piece of land in the industrial area of Karlsruhe-Rheinhafen and built a second facility. Since 2005, the production, storage and shipping of laboratory chemicals have been located in this facility on the Rhine port site . In June 2013, the chemicals store in the Rhine port was enlarged by around 50% to 8,000 square meters. 
In 2020, a logistics center was built in the Knielingen district. It offers around 7,000 square meters of additional storage space and also includes an automated small parts warehouse. 
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"FedEx". Wikipedia, Wikimedia Foundation, 2 June 2022, at 12:32 (UTC) , https://en.wikipedia.org/wiki/FedEx